Otilonium bromide

Oral
Gastrointestinal spasm

Should be taken on an empty stomach.

Patient with benign prostatic hyperplasia, pyloric stenosis, and glaucoma. Pregnancy and lactation.

Gastrointestinal disorders: Nausea, vomiting, abdominal distress.
Nervous system disorders: Headache, dizziness.
Skin and subcutaneous tissue disorders: Urticaria.

Description:
Mechanism of Action: Otilonium bromide is a locally-acting antispasmodic agent that blocks the voltage-dependent Ca channels, thus relaxing the gastrointestinal smooth muscle. It also binds to the muscarinic receptor and tachykinin receptor.
Pharmacokinetics:
Absorption: Bioavailability: 3%. Time to peak plasma concentration: 2 hours.
Excretion: Via faeces (95-97%).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 72092, Otilonium Bromide. https://pubchem.ncbi.nlm.nih.gov/compound/Otilonium-Bromide. Accessed Oct. 25, 2023.

Store below 30°C.

Antispasmodics

A03AB06 - otilonium bromide ; Belongs to the class of synthetic anticholinergics, quaternary ammonium compounds. Used in the treatment of functional bowel disorders.

Triantafillidis JK and Malgarinos G. Long-Term Efficacy and Safety of Otilonium Bromide in the Management of Irritable Bowel Syndrome: A Literature Review. Clin Exp Gastroenterol. 2014 Apr;7:75-82. doi: 10.2147/CEG.S46291. Accessed 12/05/2023. PMID: 24741324

Anon. Otilonium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/05/2023.

Buckingham R (ed). Otilonium Bromide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2023.

Spasmomen (A. Menarini Philippines, Inc). MIMS Philippines. http://www.mims.com/philippines. Accessed 12/05/2023.

Spasmomen Dragees 40 mg (A. Menarini Hong Kong Ltd). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 12/05/2023.